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Widefield Microscopy as a Screening Tool for Three-Dimensional Cell Culture

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September 23, 2020

Introduction

In the body, cells are typically embedded inside ECM or are in direct physical contact with cells from either the same or different lineages. Three-dimensional (3D) in vitro cell culture platforms are motivated by the need to work with cellular models that better recapitulate the cellular microenvironment. Different biological readouts from 3D cell models have been described including the analysis of cell lysates using analytical methods, such as plate reader-based luminescence or fluorescence measurements. However, high throughput widefield imaging methods have been demonstrated as promising techniques for morphological characterization and phenotypic screening in various 3D culture models.

 

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