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γH2AX Foci Spot Counting as a Determination of Genotoxicity
February 16, 2018
Related Application: Genotoxicity
Double strand DNA breaks represent a critical form of genotoxic effect defined by histone 2AX (H2AX) phosphorylation to γH2AX as part of the DNA repair process. Following immunostaining, automated fluorescent imaging and dual mask spot counting is performed to quantify labeled foci per nuclei after drug treatment.