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Label-Free Tumor Invasion Assay Using 3D Tumor Spheroids
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June 19, 2018
A surrogate model for metastasis is constructed using a co-culture of cancer cells and fibroblasts aggregated into a 3D spheroid (the tumor) embedded in chemoattractant-infused matrigel (surrounding tissue). Over time, the cancer cells invade into the matrigel which can be inhibited by drugs that block chemoattractant-cancer cell association.